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Normal saline, 70 mg/kg b.w. Subcutaneous (s.c.) morphine for 7 days for sensitization as described earlier., The locomotor activity of the rats was evaluated in terms of the frequency of crossings and rearing of the rats by placing them in a box sized 30×30×30 cm, divided in 9 squares, by vertical and horizontal lines separated by 10 cm each. Rearing was defined as standing of the rat on its 2 hind limbs. A crossing was defined as movement of the rat from one square to another. 
Sensitized rats with a 25% increase in baseline crossing or rearing activity (our unpublished data) were screened and were randomly divided into 3 groups (n=6) and were treated with 0.5 mL i.p.
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